Introduction: Vitiligo is a chronic skin condition characterized by depigmentation, which significantly impacts patients’ quality of life (QoL) due to its visible nature and associated social stigma. This study aims to evaluate the effectiveness of cosmetic dermatology interventions in improving the QoL for vitiligo patients. Methods: Patients with vitiligo were assessed before and after receiving various cosmetic treatments, including depigmentation, camouflage therapy, and skin grafting. Quality of life was measured using validated questionnaires, such as the Dermatology Life Quality Index (DLQI) and Vitiligo-specific Quality of Life Instrument (VitiQoL). Results: The study found a substantial improvement in QoL scores post-treatment. Patients reported enhanced physical appearance, psychological well-being, and social interactions, indicating the positive impact of cosmetic dermatology on multiple dimensions of their lives. Conclusions: Cosmetic dermatology significantly improves the quality of life for vitiligo patients by addressing both the physical symptoms and the psychological and social challenges associated with the condition. Integrating cosmetic treatments into the holistic management of vitiligo is crucial for enhancing patient well-being.